What to Watch on Sunday: Huge premiere night starts with Amazing Race

Amazing Race 15 (8pm, CBS) - Contestants begin their journey tonight in Los Angeles, but soon find themselves in Tokyo trying to survive a Japanese game show. Lots of great teams this year, but one stands out for me: two Harlem Globetrotters.

The Simpsons (8pm, Fox) - It's season 21 for our favorite Springfield family, and tonight's debut was co-written by Seth Rogen. Rogen also lends his voice to the trainer getting Homer ready for his super hero movie role. Look for lots of big name guest stars this season, such as Sarah Silverman and Anne Hathaway.

Cleveland Show (8:30, Fox) - A "Family Guy" spinoff from Seth McFarlane and Mike Henry about a divorced father who returns to his hometown and romances his first love, who now has children of her own. Fox also debuts "Family Man," and "American Dad" tonight.

Desperate Housewives (9pm, ABC) - A "beloved character" is attacked in tonight's premiere, and much of season 6 will focus on solving the question of whodunnit. There's a mysterious new couple on the block, played by Drea de Matteo ("Sopranos") and Jeffrey Nordling ("24"). The show will also immediately reveal who was at the altar with Mike in last year's finale -- Susan or Katherine?

Dexter (9pm, Showtime) - Season 4 opens with Dexter in full Family Man mode. He's married now with two stepchildren and a new baby. The only problem is he's still dicing up bad guys in his spare time. Keith Carradine returns as Agent Frank Lundy get Dexter's help in tracking a new serial killer called The Trinity Killer, because he kills in threes. A mind-blowingly creepy John Lithgow plays Trinity.

Californication (10pm, Showtime) - Hank is up to his old nasty tricks this season, and has expanded his tom-catting territory to academia.  

Cold Case (10pm, CBS) - For the seventh season debut, the team is investigating the 1966 murder of a young woman aboard a luxury ocean liner.

Brothers & Sisters (10pm, ABC) - Another season, another medical crisis for an unnamed member of the Walker family. Also, this season, Kitty and Robert try to save their marriage, and Sarah has a fling with "Dancing with the Stars" and "Sex in the City" French hottie Gilles Marini. And Nora and Holly will fight a lot, of course.

There's also some great stuff airing tonight in non-premiere news...

Drop Dead Diva (9pm, Lifetime) - Jane's mother makes an unexpected visit (different from Deb's mother? So confusing). Nia Vardalos and Faith Prince guest star.

Mad Men (10pm, AMC) -It's going to be hard to top last week's bloody good episode, but then I've never seen a bad episode of "Mad Men" -- so far. Tonight, Don contemplates his future and Peggy receives a luxurious gift.

Bored to Death (9:30pm, HBO) - Kristin Wiig makes a guest appearance and hires Jonathan to find out if her boyfriend is cheating on her. Ray (Zach Galifiankis) brings Jonathan along for moral support when he goes for his colonic. That's friendship.