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The Spanish Flu Pandemic strikes home

It's been nearly a hundred years since the Spanish flu pandemic devastated so many families in Raleigh and beyond. In 1960, N&O writer Lucy Daniels gave readers a look back at that terrible winter.

Half a million Americans died that fall and winter of 1918-19 before the influenza epidemic ran its course. Thousands died in North Carolina ...

The flu's toll was nearly four times the number of U. S. servicemen who died in all of World War I. And nearly 50,000 of our military deaths in that war were attributed to the flu. Many young men died before they glimpsed action -- either still in this country or on transport ships headed for Europe....

The siege of 1918-19 came in three distinct waves -- the first in the spring and summer of 1918; the second in the fall of 1918; and the third in the winter and spring of 1919 Of these, the first and third were relatively mild and the second inconceivably deadly...

Cases in 1918 seemed to fall in three main groups. There was a mild form from which the patient soon felt better but then developed pneumonia and often died. Another type, which was moderately severe with mild pulmonary complications, was rarely fatal. And the third type was sudden and so severe, with death so soon (within 36 to 48 hours) that the lung infection scarcely had time to get a start. All three types had at least on thing in common -- no effective treatment available.

Apprehension and dread gave way to panic and confusion. Some towns adopted plague-like precautions. In Raleigh, for instance, there was a ban against public assembly. Not only were the schools and movie houses closed, but for the first time in the city's history the churches were shut down. All from early October till late November.

This was common procedure throughout North Carolina and in some places even stronger measures were enforced. Rocky Mount closed its mills. In Jackson a maximum of 10 persons was allowed in any store at one time. Winston-Salem closed its barber shops and required all funerals to be private. The tobacco markets were closed and county fairs cancelled. School children, who for some reason suffered less than other age groups, were set to work picking the cotton so badly needed in the war. This was considered a healthy occupation because it was done outdoors.

But despite these precautions, influenza spread at a wild and terrifying rate. And people began to employ safety measures of their own. In addition to the sterilization of dishes and other precautions advocated by the Public Health Department, many took to wearing gauze masks everywhere -- often so dirty that they in themselves were menaces. Others wore little bags of asafetida around their necks to ward off infection. This may have been some benefit, because its odor was so foul that other people shunned the wearer.

There was no positive prevention, nor any effective drugs for the sick. Nothing but aspirin, quinine, sedatives and mild laxatives. Nearly every patent medicine proclaimed itself at least a tonic or partial cure. In September Congress appropriated a million dollars for use in the national emergency, and after that the U. S. Health Department was besieged by letters from quacks offering them a "sure cure for a reasonable sum."

But in reality there was nothing. Dr. Hubert Haywood, who worked in Raleigh throughout the epidemic, recalls that the disease "hit us like a ton of bricks.... It was the most heartbreaking experience of my career. We were so helpless."

"The truly unsung heroes of the day," Dr. Haywood adds, "were those who volunteered as nurses and orderlies to tend the sick." In Wilmington where the influenza got a devastating start before its savage rampage north-westward through North Carolina, all the nurses were stricken -- some fatally. In Raleigh, where over 200 volunteered, two young women were remembered as tragic examples of heroism. Miss Lucy Page, a trained nurse of about 30, and Elizah Riddick, 24, who worked tirelessly as a volunteer at State College before she was stricken. Both were strong, vital young women, hardly the type to die.

Elizah Riddick's death came only one week after that of her brother "Rout."

Rex Hospital, as well as other Raleigh facilities, was jammed to overflowing and had to turn even critical cases away. In some homes whole families were stricken, with no one to nurse or cook or even attend to the demands of death when it occurred. At State College, dormitories and the YMCA building were converted to hospital wards for both college students and some of the more serious cases from the Army's tank training recruits at Camp Polk.

Out at that camp, which had been literally thrown up on the old fair grounds, boys from all over the United States were dying on canvas cots set up in the cattle sheds. Some of the military, who could afford it, took rooms at the hotels in town and called in local doctors. But soon the hotels, too, had no more vacancies.

And so Raleigh, like most other cities, set up public emergency hospitals. ... At first some people refused to go to these hospitals, and two days after they were opened the city commissioners passed an ordinance requiring all influenza cases untreatable at home to be moved to the hospitals.

Besides these makeshift hospitals, soup kitchens were set up in various places throughout the city....

Raleigh was typical of cities throughout North Carolina and the nation.... In nearly every community in the country it was impossible to step outside without seeing coffins, hearses, funeral processions. Railroad stations were piled high with flag-draped boxes waiting transportation home.

There was a shortage of coffins everywhere, and ministers, as well as embalmers and grave diggers, were often unable to keep up with their work. -- The News & Observer 2/7/1960


Photos courtesy of the Library of Congress

BioCryst revenues drop in fourth quarter

Durham drug company BioCryst Pharmaceuticals announced fourth quarter earnings today that missed Wall Street estimates.

The company reported revenue of $5.2 million for the quarter, down from $16.7 million during the same period in 2010. That was below the $5.5 million that was the mean estimate among analysts who cover the company.

BioCryst attributed the drop in revenue to a $9 million decrease in collaboration revenue from the Department of Health and Human Services/Biomedical Advanced Research.

Those revenues were for the development of BioCryst's flu treatment peramivir. Clinical trials for the drug were completed in 2010.

BioCryst 's revenue down; says gout medicine shows promise

Drug company BioCryst Pharmaceuticals reported a wider third quarter loss due to reduced revenue from its flu treatment.

Revenues for the quarter were $5.2 million, down from $12 million during the same period a year ago.

BioCryst attributed the decline to lower collaboration revenue from the federal government in relation to the ongoing development of peramivir, its flu treatment.

The net loss for the quarter was $14.5 million, or 32 cents per share, compared to a loss of 24 cents per share a year ago. The consensus among analysts who cover the company was a loss of 31 cents a share.
 
None of BioCryst's drugs have been approved for the U.S. market. Its flu treatment peramivir was approved last year in Japan and Korea.

Peramivir is in Phase III clinical trials, the final phase required by U.S. regulators before a company can seek approval of a drug.

Urgent Cares of America offering free flu shots

Urgent Cares of America has started offering free flu vaccinations at its nine North Carolina locations.

The company, which is based in Clayton, offered free vaccines for children and students earlier this month. Most of the clinics have run out of the children's vaccines but are now offering free vaccines to any adults who wish to get one while supplies last.

By offering the program, Urgent Cares is joining a growing list of retailers and clinics offering free or discounted flu shots. Following last year's flu shot shortage, many manufacturers produced extra doses and stores ordered surplus supplies. (See News & Observer story, Dec. 24, 2010.)

Urgent Cares of America operates locations in Asheville, Boone, Cary, Clayton, Garner, Fuquay-Varina and Wake Forest. For more information or to find a location, visit www.rucn.info or call 550-0821.

At Duke: Finding the flu before symptoms emerge

At Duke University, researchers are looking for ways to detect the flu before symptoms arise.

A research team has a Department of Defense grant to investigate this using genetic markers, Sarah Avery reports today.

Researchers are enlisting the help of Duke students, 500 to 800 of them, to whom they are offering $25 gift cards to get involved.

Here's the story.

 

Kerr begins selling flu vaccine

Kerr Drug has started selling flu shots — joining other drug store chains who are attempting to get a jump on the season.

Drug store executives say they are expecting unprecedented demand and Kerr has trained an additional 115 pharmacists to immunize customers. The company has 18 stores in the Triangle.

Drug-store chains begin flu shots today

CVS and Walgreens began selling seasonal flu shots this morning, about a month earlier than last year as the chains try to attract new customers amid fears of swine flu.

CVS and Walgreens, which each have about 6,900 stores around the country, also announced that they will give away flu shots to the unemployed or uninsured.

But the freebies won't be simple to get.

Flu leads duke to cancel summer program

A summer program at Duke University has been canceled following a flu outbreak on campus.

The second of two summer sessions of Duke's Talent Identification Program was canceled Wednesday after more than 25 of the 260 participants tested positive for the flu or exhibited flu symptoms, according to campus officials.

All the cases are deemed mild to moderate and no student has been hospitalized. The three-week session for academically gifted teenagers was being held on Duke's East Campus and had been scheduled through Aug. 1.

"Although none of the students seems to be in any serious danger, we decided to err on the side of caution and cancel the program to reduce the accelerating risk of infection among the other participants,” said Martha Putallaz, Duke TIP’s executive director.

Other Duke summer programs located in other parts of the campus, including Duke TIP’s West Campus programs, are continuing as scheduled, with program administrators keeping a close watch on the health of their participants and others, according to a university press release.

Several programs, such as those of the American Dance Festival and Duke Youth Programs, are scheduled to end this weekend, the release states.

“We’ve increased surveillance for influenza infections in our community throughout the summer,” said Christopher Woods, a Duke infectious disease expert and part of the medical team advising the programs.

GSK adds temp workers in Zebulon

GlaxoSmithKline recently added about 30 temporary workers at its Zebulon manufacturing plant to help handle increasing production of the Relenza flu drug.

But the plant's workforce, now about 600 full-time employees, remains down sharply from 900 in October, said GSK spokesman Kevin Colgan. GSK has been cutting costs and jobs worldwide to offset slowing drug sales.

The British drug maker also employs about 4,800 at its North American headquarters in Research Triangle Park.

GSK is seeing surging demand for Relenza amid global fears about swine flu. Relenza is packaged at GSK's manufacturing plant in Zebulon, and at a factory in France.

As the company announced stronger second-quarter profit and revenue today, GSK also said it expects to triple its annual production capacity of Relenza by the end of the year. GSK previously announced it had a maximum capacity of 60 million courses and now expects to make 190 courses a year.

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