The CapTrust Tower at North Hills has leased nearly 19,000 square feet to two new tenants.
Wasserman Media Group is moving into 10,294 square feet on the 10th floor. NovaQuest Capital Management will occupy 8,586 square feet on the building's ninth floor.
Wasserman Media Group is a global sports and entertainment company based in Los Angeles.
NovaQuest Capital Management manages investments in the biotech and pharmaceutical sectors.
Developed by Duke Realty and Kane Realty, the 275,000-square-foot, 17-story CapTrust Tower opened in 2009.
It is home to some of the priciest office space in the Triangle with asking rates above $30 a square foot.
The building was 67 percent occupied in the fourth quarter of 2010, according to a Grubb & Ellis Thomas Linderman Graham survey of the Triangle office market.
A private-equity firm started by former Quintiles executives is seeking to raise $500 million to invest in health-care companies.