GlaxoSmithKline is eliminating an undisclosed number of research and development jobs in Research Triangle Park.
The job losses are part of reductions in GSK's Neurosciences Medicine Development Center.
The total job cuts in the U.S. are fewer than 50 with less than half of those located in RTP, said Melinda Stubbee, a spokeswoman.
The rest of the cuts are at various clinical trial sites in the U.S., but not at the company's R&D facilities in the Philadelphia area.
GSK empoys about 4,000 people in RTP.
The company made an internal announcement about the job cuts on Monday.