The biggest name is Duke's Thaddeus Lewis, who sprained his left foot at Clemson, missed practice Tuesday, and has been limited the rest of the week. If he doesn't start, it would break a string of 33 consecutive starts.
Out: Duke — RB Clifford Harris (arm), DE Wesley Oglesby (leg); VT — C Barrett Mears (ankle), FS Lorenzo Williams (knee)
Doubtful: Duke — QB Thaddeus Lewis (foot)
Questionable: Duke — DE Ayanga Okpokowuruk (leg)
Probable: Duke — CB Jabari Marshall (leg); VT — WR Dyrell Roberts (shoulder)
Also, Virginia Tech receiver Jarrett Boykin (illness) and defensive end Jason Worilds (shoulder) will play.