Clemson coach Tommy Bowden resigned on Monday with six games left in the season, the school announced after multiple media outlets broke the story Monday afternoon.
Receivers coach Dabo Swinney will coach the remainder of the season.
The Tigers are 3-3, with a pair of wins over Division I-AA teams, in what was supposed to be their first ACC championship season since 1991.
Bowden went 72-45 in his 10th season at Clemson, with a 43-32 ACC record.
Clemson AD Terry Don Phillips said Bowden walked away under his own accord, albeit under intense pressure and with the likelihood he would have been fired at the end of the season.
"There wasn’t a gun to his head," Phillips said. "He put it on the table for the sake of the program. I agreed.”
Bowden will be paid through the end of the season, then get $3.5 million as a buyout negotiated in the contract extension both sides agreed to last December.
The Tigers opened the season ranked No. 9 in the country but lost their opener, 34-10 to Alabama and the season was over before it began.
After beating N.C. State in their ACC opener, the Tigers lost to Maryland at home and at Wake Forest in a Thursday night ESPN showcase.
Swinney, a receiver on Alabama's 1992 national title team, is in his sixth season at Clemson on Bowden's staff.
The Associated Press contributed to this report