N.C. State will face Florida State's top-rated defense without three of its starters on the offensive line, including guard Zach Allen, who is out for the rest of the season with a foot injury.
Allen, who started the first five games at right guard, got his right foot rolled up from behind during the third quarter of N.C. State's 44-37 loss to Miami last Saturday.
Left tackle Rob Crisp will miss his fifth straight game with a back injury and tackle Andrew Wallace will miss his second straight game with an injured left ankle. Wallace and Allen suffered similar injuries on similar type of plays.
Cameron Fordham is expected to start at right guard for Allen with R.J. Mattes starting his second straight game at left tackle. Duran Christophe will start at left guard and Tyson Chandler will make his fifth straight start at right tackle.
Center Joe Thuney will also play Saturday, coach Tom O'Brien said, with center Cam Wentz moving to right guard when Thuney plays.
Running back James Washington will miss his second straight with an ankle injury.
N.C. State faces No. 3 Florida State at 8 p.m. on Saturday. The Seminoles (5-0) lead the ACC in total defense, scoring defense, rushing defense, pass defense and sacks.